Bachelorstudiengang PO2017

- Chemie und Biotechnologie B.Sc.

• 5311 Angewandte Organische Analytik (V, 2 SWS; S, 1 SWS) (Teilmodul)
• 5210 Instrumentelle Analytik Teil 1 und 2 (P, 2 SWS)

- Chemieingenieurwesen B.Eng.

• 4210 Instrumentelle Analytik I für B.Eng. (P, 2 SWS)

Masterstudiengang PO2017

- Angewandte Chemie M.Sc.

• 5703 Prozessanalytik (V, 2 SWS) (Teilmodul)
• 5900 Vertiefungspraktikum (P)
• 5950 Projektmodul (P)
• 5813 AKIA 1 (S, 3 SWS) (Teilmodul)
• 5814 Umweltschutzanalytik (V, 2 SWS; Ü, 2 SWS; S, 2 SWS)
• 5815 Hauptseminar Instrumentelle Analytik (S, 4 SWS)
• 5822 Spektroskopische Methoden (S, 2 SWS) (Teilmodul)

Bachelorstudiengang PO2024

- Chemie und Biotechnologie B.Sc.

• xxxx Angewandte Organische Analytik
  • Sepktroskopische Methoden und Strukturanalytik organischer Verbindungen (V, 2 SWS; Ü, 2 SWS)
• xxxx Instrumentelle Analytik Teil 1 und 2 (P, 2 SWS) (Teilmodul)
• xxxx Strategien der Instrumentellen Analytik
  • Strategien in der organischen Analytik (V, 2 SWS; P, 0.5 SWS) (Teilmodul)

- Chemieingenieurwesen B.Eng.

• xxxx Instrumentelle Analytik I für B.Eng. (P, 2 SWS) (Teilmodul)

Masterstudiengang PO2024

- Angewandte Chemie M.Sc.

• xxxx Ausgewählte Kapitel der Instrumentellen Analytik (AKIA)
  • xxxx AKIA-2 (V, 1 SWS; S, 1 SWS)
• xxxx Projekt Spezielle Methoden der Instrumentellen Analytik 1 (P, 3 SWS) (Teilmodul)
• xxxx Anwendungen der Spektroskopie in der Analytik (ASA)
  • Organische Spurenanalytik (V, 1 SWS; S, 1 SWS)
  • Prozessanalytische Technologien (V, 1 SWS; S, 1 SWS)
• xxxx Projekt Spezielle Methoden der Instrumentellen Analytik 2 (P, 3 SWS) (Teilmodul)
• xxxx Projekt Probennahme (P, 6 SWS) 
• xxxx Umweltschutzanalytik (V, 2 SWS; Ü, 2 SWS)
• xxxx Projekt Umweltschutzanalytik (P, 5 SWS; S, 1 SWS)

Betreuung von kooperativen Promotionen.

   Berufliche Erfahrung

01/ 2021 bis heute       Vorstandsmitglied im Arbeitskreis Prozessanalytik (AK PAT) der Gesellschaft Deutscher Chemiker (GDCh)

03/ 2018 bis heute       Dekan Fachbereich Chemie

03/ 2013 bis heute       Professor für Instrumentelle Analytik
                                       Fachbereich Chemie, Hochschule Niederrhein

10/ 2011 bis 02/ 2013  Senior Scientist Analysis
                                       Analytical Research Center, DSM Nutritional Products Ltd.,
                                       Kaiseraugst, Schweiz

05/ 2007 bis 09/ 2011  Groupleader and Senior Scientist Structure Analysis
                                       Department of Medicinal Chemistry, Merck Research Laboratories, 
                                       vormals N.V. Organon, Oss, The Netherlands

04/ 2002 bis 04/ 2007  NMR Manager
                                       Drug Discovery, Intervet Innovation GmbH, Schwabenheim

01/ 2002 bis 03/ 2002  Wissenschaftlicher Angestellter
                                        Ruhr-Universität Bochum

12/ 1998 bis 11/ 2001  Research Associate
                                        Department of Chemistry, The University of Chicago, Chicago, IL, USA

   Bildung

03/ 1998                      Promotion
                                        Institut für Organische Chemie, Eberhard Karls Universität Tübingen

02/ 1995                      Diplom in Chemie
                                        Institut für Organische Chemie, Eberhard Karls Universität Tübingen

05/ 1988                      Abitur
                                        Albrecht Dürer Gymnasium, Hagen

   Stipendien und Auszeichnungen

12/1998 bis 05/ 2001  Alexander von Humboldt-Stipendiat (Feodor Lynen-Stipendium)
                                       The University of Chicago, Chicago, IL, USA

     1998                       Förderpreis der Fakultät für Chemie und Pharmazie der Universität Tübingen

03/ 1995 bis 02/ 1998  Kollegiat und Stipendiat des Graduiertenkollegs "Quantitative Analytik
                                        pharmazeutisch und biochemisch relevanter Substanzen"
                                        an der Universität Tübingen

10/1992 bis 04/ 1993   ERASMUS Stipendiat
                                        Université Claude Bernard Lyon I & Ecole Superieure de Chimie Industrielle
                                        de Lyon, Frankreich 

Research interests

A brief German summary of the research interest can be found in the Mitteilungen 3/ 2019 (p. 91f)  der Fachgruppe Umweltchemie und Ökotoxikologie der GDCh. 

• Pharmaceuticals in Waters 
• Advanced Oxidation Processes for the removal of pharmaceuticals in waste water
• Chemical kinetics of photo-induced degradation of pharmaceuticals
• Environmental analysis using chromatography coupled to mass spectrometry

             For an impression: Watch this video 

The project Enz4Water combines the research efforts of several groups to develop enzymatic filters for use as a fourth purification stage in wastewater treatment plants.

• Micro Process Analytical Technology
• Spectroscopy for process analysis

• Fieldable spectroscopy and mobile labs

• NMR spectroscopy
• Covariance NMR
  • To learn more about HeteroCovariance Spectroscopy and its application to Process Analytical Technology watch this video
  • To learn much more about Covariance NMR in general and its most recent applications wath the full video

Collaborations

ThermoFisher Scientific

Gerstel 

This site is still under construction.

Mahler L, Tasdemir E., Nickisch-Hartfiel, A., Mayer, C, and Jaeger M. Monitoring of the Biotechnological Production of Dihydroxyacetone Using a Low‐Field 1H NMR Spectrometer. Biotechnology and Bioengineering. 2024, 1-9.

doi.org/10.1002/bit.28901

Mahler L, Mayer, C, and Jaeger M. How Two‐Dimensional Heterocovariance Spectroscopy and Data Fusion Level out the Inadequacies of Compact Spectrometers. Applied Research. 2024, e202400175.

doi.org/10.1002/appl.202400175

Hermsen A, Hertel F, Wilbert D, Mayer C, and Jaeger M. MD and DFT Calculations to Analyze Raman and SERS Spectra of Paraquat—From Computer Aided Spectra Interpretation to Pesticide Identification. Applied Research. 2024, e2400182.

doi.org/10.1002/appl.202400182

Voigt, M., and Jaeger, M. Efficiency increased advanced oxidation processes by persalts for the elimination of pharmaceuticals in waterbodies: a short review. Discover Chemical Engineering. 2024, 4, 16.

doi.org/10.1007/s43938-024-00052-x

Schmiemann D., Bicks F., Bartels I., Cordes A., Bachmann F., Cordes A., Jaeger M.,  Gutmann J.S.,  and K. Hoffmann‐Jacobsen, Enzymatic degradability of diclofenac ozonation products: Amechanistic analysis. Chemosphere, 2024, 358, 142112

doi.org/10.1016/j.chemosphere.2024.142112

Voigt, M., Dluziak, J.-M., Wellen, N., and Jaeger, M. Mechanistic study of the electrochemical oxidation of fluoroquinolones: Ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin. Chemosphere. 2024, 355, 141763.

doi.org/10.1016/j.chemosphere.2024.141763

Hermsen A, Hertel F, Wilbert D, Gronau T, Mayer C, and Jaeger M. Pesticide Identification Using Surface-Enhanced Raman Spectroscopy and Density Functional Theory Calculations: From Structural Insights to On-Site Detection. Applied Spectroscopy. 2024, 78, 616-626.

doi.org/10.1177/00037028241236501

Voigt, M., Dluziak, JM., Wellen, N., Langerbein V., and Jaeger M. Comparison of photoinduced and electrochemically induced degradation of venlafaxine. Environ Sci Pollut Res . 2024, 31, 13442-13454.

doi.org/10.1007/s11356-024-32018-5

Voigt M., Dluziak J.-M., Wellen N., Langerbein V., and Jaeger M. Univariate and multivariate kinetic and structural analysis of photoinduced tetracycline degradation. Tox. Env. Chem., 2023, 105, 221-237.

doi.org/10.1080/02772248.2023.2274575

Bartels, I., Jaeger, M., and Schmidt, T.C. Determination of anti-SARS-CoV-2 virustatic pharmaceuticals in the aquatic environment using high-performance liquid chromatography high-resolution mass spectrometry. Analytical and Bioanalytical Chemistry, 2023, 415, 5365-5377.

doi.org/10.1007/s00216-023-04811-7

Szykuła M., Offermans T., Lischtschenko O., Meurs J., Guenther D., Mattley Y., Jaeger M., and Honing M., Predicting Animal Welfare Labels from Pork Fat Using Raman Spectroscopy and Chemometrics. Applied Chemistry, 2023, 3, 279-289. doi.org/10.3390/appliedchem3020017

Reinders, L.M.H., Klassen, M.D., Endres, P., Jaeger, M., Schmidt, T.C., Teutenberg, T., and Tuerk, J. Quality Control of Personalized Drug Products - Identity and Quantity of Monoclonal Antibodies as Active Pharmaceutical Ingredient. Journal of Pharmaceutical Sciences, 2023, 112, 2143 - 2145.

doi.org/0.1016/j.xphs.2023.06.009

Voigt M., Dluziak J.-M., Wellen N.,Langerbein V., and Jaeger M. Photoinduced degradation of three azole compounds from 3rd EU watchlist monitored by high-resolution higher-order mass spectrometry – Part II: A critical in silico ecotoxicity assessment and application of ecotoxicty equivalents. Environmental Advances, 2023, 11, 100356.

doi.org/10.1016/j.envadv.2023.100356

Schmiemann D., Hohenschon L., Bartels I., Hermsen A., Bachmann F., Cordes A., Jaeger M.,  Gutmann J.S.,  and K. Hoffmann‐Jacobsen, Enzymatic post-treatment of ozonation: laccase-mediated removal of the by-products of acetaminophen ozonation, Environmental Science and Pollution Research, 2023, 30, 53128–53139.

doi.org/10.1007/s11356-023-25913-w

Mahler, L., Legner, R., and M. Jaeger, Heterocovariance and data fusion in PAT. G.I.T. Laboratory Journal 2023, X-X, yy-zz; Spektrometer- und Datenkombination für die Prozessanalytik . GIT - Labor-Fachzeitschrift 2023, 67, 30-32.

bit.ly/GIT-Jaeger

Voigt M., Langerbein V., Dluziak J.-M., Wellen N., and Jaeger M. The role of the direct and indirect mechanism in the advanced oxidation process induced degradation of ciprofloxacin. Tox. Env. Chem., 2023, 105, 1-18.

doi.org/10.1080/02772248.2023.2168005

Reinders, L.M.H., Klassen, M.D., Endres, P., Krumm, A., Jaeger, M., Schmidt, T.C., and Teutenberg, T. Development of a Two-dimensional Liquid Chromatography High-Resolution Mass Spectrometry Method for the Characterization of Monoclonal Antibodies in Cell-Free Culture Supernatant via FcR Affinity Chromatography. Chromatographia, 2023, 86, 79 - 85.

doi.org/10.1007/s10337-022-04228-x

Cattelaens F., Jaeger M., and Myrdek T. Purification of carboxymethylated fatty alcohol derivates using ion exchange resins. Journal of Surfactants and Detergents, 2023, 26, 111-117. 

doi.org/10.1002/jsde.12641

Reinders L.M.H., Noelle D., Klassen M.D., Jaeger M., Schmidt T.C., Tuerk J., Teutenberg T., Development and validation of a method for airborne monoclonal antibodies to quantify workplace exposure, Journal of Pharmaceutical and Biomedical Analysis, 2022, 115046.

doi.org/10.1016/j.jpba.2022.115046

Voigt M., Wellen N., Dluziak J.-M., Langerbein V., and Jaeger M. Photoinduced degradation of three azole compounds from 3rd EU watchlist monitored by high-resolution higher-order mass spectrometry – Part I: A mechanistic study. Environmental Advances, 2022, 9, 100288.

doi.org/10.1016/j.envadv.2022.100288

Reinders, L.M.H., Klassen, M.D., Teutenberg, T., Jaeger, M., and Schmidt, T.C. Comparison of originator and biosimilar monoclonal antibodies using HRMS, Fc affinity chromatography, and 2D-HPLC. Anal. Bioanal. Chem. 414, 6761-6769, 2022.

doi.org/10.1007/s00216-022-04236-8

Hermes, P.; Hermsen, A.; Jaeger, M.; Gutmann, J.S.; Strehmel, V.; Strehmel, B. Challenges and limits of upconversion nanoparticles for cationic photopolymerization with UV initiators excited at 980 nm. Polym. Chem. 13, 4879-4886, 2022.

doi.org/10.1039/D2PY00460G

Hermsen A., Schoettl J., Hertel F., Cerullo M., Schlueter A., Lehmann C.W., Mayer, C., and Jaeger M. Green Textile Materials for Surface Enhanced Raman Spectroscopy Identification of Pesticides Using a Raman Handheld Spectrometer for In-Field Detection. Appl. Spectrosc. 76, 1222-1233, 2022.

doi.org/10.1177/00037028221097130

Voigt, M.; Langerbein, V.; Jaeger, M. In silico ecotoxicity assessment of photoinduced imidacloprid degradation using HPLC–HRMS, QSAR and ecotoxicity equivalents. Environmental Sciences Europe 2022, 34, 47.

doi.org/10.1186/s12302-022-00616-0

Hermsen A., Lamers D., Schoettl J., Mayer, C., and Jaeger M. In-field detection method for imidacloprid by surface enhanced Raman spectroscopy. Tox. Env. Chem. 104, 36-54, 2022.

doi.org/10.1080/02772248.2021.1991929

Reinders, L.M.H., Klassen, M.D., Teutenberg, T., Jaeger, M., and Schmidt, T.C. Development of a multidimensional online method for the characterization and quantification of monoclonal antibodies using immobilized flow-through enzyme reactors. Anal. Bioanal. Chem. 413, 7119–7128, 2021.

doi.org/10.1007/s00216-021-03683-z.

Voigt,M.; Bartels,I.; Schmiemann, D.; Votel, L.; Hoffmann-Jacobsen, K.; Jaeger, M. Metoprolol and Its Degradation and Transformation Products Using AOPs—Assessment of Aquatic Ecotoxicity Using QSAR. Molecules 2021, 26, 3102.

doi.org/10.3390/molecules26113102

Reinders, L.M.H., Klassen, M.D., vom Eyser, C., Teutenberg, T., Jaeger, M., Schmidt, T.C., and J. Tuerk, A Quality control of cytostatic drug preparations-comparison of workflow and performance of Raman/UV and high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). Anal. Bioanal. Chem. 2021, 413, 2587-2596.

doi.org/10.1007/s00216-021-03223-9.

Legner, R., Voigt, M., Servatius, C., Klein, J., Hambitzer, A., and Jaeger, M. A Four-Level Maturity Index for Hot Peppers (Capsicum annum) Using Non-Invasive Automated Mobile Raman Spectroscopy for On-Site Testing. Appl. Sci. 2021, 11, 1614.

doi.org/10.3390/app11041614

Voigt M., and Jaeger M., Structure and QSAR analysis of photoinduced transformation products of neonicotinoids from EU watchlist for ecotoxicological assessment, Sci. Total Environ., 2021, 751, 141634.

doi.org/10.1016/j.scitotenv.2020.141634

Voigt M., Wirtz A, Hoffmann-Jacobsen K., and Jaeger M., Prior art for the development of a fourth purification stage in wastewater treatment plant for the elimination of anthropogenic micropollutants-a short-review, AIMS Environ. Sci., 2020, 7, 69–98.

doi.org/10.3934/environsci.2020005

Voigt M., Hentschel B., Theiss N., Savelsberg C., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity. Clean. Technol. 2020, 2, 74-90.

doi.org/10.3390/cleantechnol2010006

Legner R., Voigt M., Wirtz A., Friesen A., Haefner S., and Jaeger M. Using Compact Proton Nuclear Magnetic Resonance at 80 MHz and Vibrational Spectroscopies and Data Fusion for Research Octane Number and Gasoline Additive Determination, Energy & Fuels 2020, 34, 103-110.

doi.org/10.1021/acs.energyfuels.9b02944

Voigt M., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Determination of minimum inhibitory concentration and half maximal inhibitory concentration of antibiotics and their degradation products to assess the eco-toxicological potential. Tox. Env. Chem. 2019, 101, 315-338.

doi.org/10.1080/02772248.2019.1687706

Legner R., Wirtz A., Koza T, Tetzlaff T., Nickisch-Hartfiel A., and Jaeger M., Application of green analytical chemistry to a green chemistry process: Magnetic resonance and Raman spectroscopic process monitoring of continuous ethanolic fermentation. Biotechnology and Bioengineering. 2019, 116, 2874-2883. (open access)

doi.org/10.1002/bit.27112

Schmitz C., Yang P., Guelz A, Glaeser M, Horst J, Jaeger M., and Strehmel B., New High‐Power LEDs Open Photochemistry for Near‐Infrared‐Sensitized Radical and Cationic Photopolymerization. Angew. Chem. Int. Ed. 2019, 58, 4400-4404.

dx.doi.org/10.1002/anie.201813696

Voigt M., Legner R., Haefner S., Friesen A., Wirtz A., and Jaeger M., Using fieldable spectrometers and chemometric methods to determine RON of gasoline from petrol stations: A comparison of low-field ¹H NMR@80 MHz, handheld RAMAN and benchtop NIR. Fuel. 2019, 236, 829-835.

dx.doi.org/10.1016/j.fuel.2018.09.006

Voigt M., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Elimination of macrolides in water bodies using photochemical oxidation. AIMS Environ. Sci. 2018, 5, 372-388.

dx.doi.org/10.3934/environsci.2018.5.372

Legner R., Wirtz A., and Jaeger M., Using Compact ¹H NMR, NIR and Raman Spectroscopy Combined with Multivariate Data Analysis to Monitor a Biocatalyzed Reaction in a Microreaction System, J. Spectrosc. 2018, 2018, 11 pages. (open access)

doi.org/10.1155/2018/5120789

Wunschik D.S., Ingenbosch K.N., Zaehres M., Horst J., Mayer C., Jaeger M., Strehmel V., Dornbusch M., and Hoffmann-Jacobsen K., Biocatalytic and solvent-free synthesis of a bio-based biscyclocarbonate, Green Chemistry. 2018, 20, 4738-4745.

doi.org/10.1039/c8gc02267d

Werres T., Leonhardt J., Jaeger M., Teutenberg, T., Critical Comparison of Liquid Chromatography Coupled to Mass Spectrometry and Three Different Ion Mobility Spectrometry Systems on Their Separation Capability for Small Isomeric Compounds, Chromatographia. 2019, 82, 251-260.

doi.org/10.1007/s10337-018-3640-z

Voigt M., Savelsberg C., and Jaeger M., Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation. J. Vis. Exp. 2018, 138, e57434. (open access and video)

dx.doi.org/10.3791/57434

Reinders L., Klassen M.D, Jaeger M., Teutenberg T., and Tuerk J., Development of an analytical method to assess the occupational health risk of therapeutic monoclonal antibodies using LC-HRMS. Anal. Bioanal. Chem. 2018, 410, 2829-2836.

dx.doi.org/10.1007/s00216-018-0966-1

Jaeger M. and Legner R., Homo- and heterocovariance NMR spectroscopy and applications to process analyticyl technology. In Spectroscopic Analyses - Developments and Applications, Zafar F. (ed.), InTech, 2017. 
https://www.intechopen.com/books/spectroscopic-analyses-developments-and-applications/homo-and-hetero-covariance-nmr-spectroscopy-and-applications-to-process-analytical-technology

Voigt M., Bartels I., Nickisch-Hartfiel A., and Jaeger M., Photoinduced degradation of sulfonamides, kinetic, and structural characterization of transformation products and assessment of environmental toxicity. Tox. Env. Chem. 2017, 99, 1304-1327.

dx.doi.org/10.1080/02772248.2017.1373777

Voigt M., Gold A., Blaesing C., Hoelscher T., and Jaeger M., Murky Waters. The Analytical Scientist. 2017, 0217, 36-41.

theanalyticalscientist.com/issues/0217/murky-waters/

Hetzel T., Blaesing C., Jaeger M., Teutenberg T., and Schmidt T.C., Characterization of peak capacity of microbore liquid chromatography columns using gradient kinetic plots. J. Chrom. A. 2017, 1485, 62-69. 

dx.doi.org/10.1016/j.chroma.2017.01.018

Voigt M., and Jaeger M., On the photodegradation of azithromycin, erythromycin, and tylosin and their transformation products - A kinetic study. Sustainable Chemistry & Pharmacy. 2017, 5, 131-140.

dx.doi.org/10.1016/j.scp.2016.12.001

Voigt M., Savelsberg C., and Jaeger M., Photodegradation of the antibiotic spiramycin studied by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry. Tox. Env. Chem. 2017, 99, 624-640.

dx.doi.org/10.1080/02772248.2017.1280039

Jaeger M., Aspers R.L.E.G. and Voigt M. (2017) Covariance NMR. In: Lindon, J.C., Tranter, G.E., and Koppenaal, D.W. (eds.) The Encyclopedia of Spectroscopy and Spectrometry, 3rd edition vol. 1, pp. 396-400.

dx.doi.org/10.1016/B978-0-12-409547-2.12106-7

Legner R., Friesen A., Voigt M., Horst J., and Jaeger M., Automation of the picoSpin 80 ¹H NMR benchtop spectrometer for high-throughput determination of the research octane number of fuels. thermoscientific application note 2016, AN52906. 

tools.thermofisher.com/content/sfs/brochures/AN52906-picoSpin-80-II-r16-12-05.pdf

Legner, R., S. Haefner, M. Voigt, J. Horst, B. Eichel, P. Naderwitz, and M. Jaeger, Micro Process Analytical Technologies. G.I.T. Laboratory Journal 2016, 20, 38-40; Mikro - Prozess - Analytik. GIT - Labor-Fachzeitschrift 2015, 59, 32-34.

Wijmenga, S.S. and M. Jaeger, 19F-Detected NMR of Multifluorinated Compounds. eMagRes. 2015, 31-36.

dx.doi.org/10.1002/9780470034590.emrstm1365

Jaeger, M., and R.L.E.G. Aspers, Covariance NMR and Small Molecule Applications. Annu. Rep. NMR Spectrosc. 2014, 83, 271-349.

doi.org/10.1016/B978-0-12-800183-7.00005-8

Aspers, R.L.E.G., K.A.M. Ampt, P. Dvortsak, M. Jaeger, and S.S Wijmenga, Fluorine detected 2D NMR experiments for the practical determination of size and sign of homonuclear F-F and heteronuclear C-F multiple bond J-coupling constants in multiple fluorinated compounds. J. Magn. Reson. 2013, 231, 79-89.

Jaeger, M., and R.L.E.G. Aspers, Steroids and NMR. Annu. Rep. NMR Spectrosc. 2012, 77, 115-258.

doi.org/10.1016/B978-0-12-397020-6.00003-9

Ampt, K.A.M., R.L.E.G. Aspers, P. Dvortsak, R.M. van der Werf, S.S. Wijmenga, and M. Jaeger, Determination of size and sign of hetero-nuclear coupling constants from 2D 19F-13C correlation spectra. J. Magn. Reson. 2012, 215, 27-33.

Kaptein A., A. Oubrie, E. de Zwart, N. Hoogenboom, J. de Wit, B. van de Kar, M. van Hoek, G. Vogel, V. de Kimpe, C. Schultz-Fademrecht, J. Borsboom, M. van Zeeland, J. Versteegh, B. Kazemier, J. de Roos, F. Wijnands, J. Dulos, M. Jaeger, P. Leandro-Garcia,  T. Barf, Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 Inhibitors. Biorg. Med. Chem. Lett. 2011, 21, 3823-3827.

Aspers, R.L.E.G., P.E.T.J. Geutjes, M. Honing, and M. Jaeger, Using indirect covariance processing for structure elucidation of small molecules in cases of spectral crowding. Magn. Reson. Chem. 2011, 49, 425-436.

Ampt, K.A.M., R.L.E.G. Aspers, M. Jaeger, P.E.T.J. Geutjes, M. Honing, and S.S. Wijmenga, Application of Fluorine NMR for structure identification of steroids. Magn. Reson. Chem. 2011, 49, 221-230.

Jaeger, M., B. Rothacker, T. Ilg, Saturation transfer differenece NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Biochem. Biophys. Res. Commun. 2008, 372, 400-406.

Chassaing, C., M. Berger, A. Heckeroth, T. Ilg, M. Jaeger, C. Kern, K. Schmid, M. Uphoff, Highly water-soluble prodrugs of anthelmintic benzimidazole carbamates: Synthesis, pharmacodynamics, and pharmacokinetics. J. Med. Chem. 2008, 51, 1111-1114.

Kolano, C., G. Bucher, H.H. Wenk, M. Jaeger, O. Schade, and W. Sander, Photochemistry of 9-fluorenone oxime phenylglyoxalate: a combined TRIR, TREPR and ab initio study. J. Phys. Org. Chem. 2004, 17, 207-214.

Ostafin, A.E., N.S. Ponomarenko, J.A. Popova, M. Jaeger, E.J. Bylina, and J.R. Norris, Jr., Characterization of expressed pigmented core light harvesting complex (LH 1) in a reaction center deficient mutant of Blastochloris viridis. Photosynth. Res., 2003, 77, 53-68.

Kolbasov, D., N. Srivatsan, N. Ponomarenko, M. Jaeger, and J.R. Norris, Jr., Modeling Charge Transfer in Oxidized Bacterial Antenna Complexes. J. Phys. Chem. B, 2003, 107, 2386-2393.

Jaeger, M., and J.R. Norris, Jr., Computation of time-resolved EPR spectra of systems exhibiting electron spin polarization complicated by magnetization transfer. J. Phys. Chem. A, 2002, 106, 3659-3664.

Jager, M., B.C. Yu, and J.R. Norris, Jr., Exploring Complex CIDEP of p-Benzosemiquinones with Time-Resolved CW-EPR. Mol. Phys., 2002, 100, 1323-1331.

Jager, M. and J.R. Norris, Jr., A Time-resolved EPR study of the Electron-spin-polarization Pathways of p-Benzoquinone. J. Magn. Reson., 2001, 150, 26-34.

Jaeger, M., P. Schuler, H.B. Stegmann, and A. Rockenbauer, Molecular recognition analyzed by observing intramolecular interconversion with EPR spectroscopy. Z. Naturforsch., B: Chem. Sci., 1998. 53(12), 1511-1519.

Jager, M., P. Schuler, H.B. Stegmann, and A. Rockenbauer, Molecular recognition. II Discrimination of specific and non-specific intermolecular interactions by means of magnetic resonance spectroscopy. Magn. Reson. Chem., 1998. 36(3), 205-210.

Jager, M. and H.B. Stegmann, Stereoelectronic effect at nitrogen in 2,6-di-tert-butyl-4-(N,N-disubstituted aminomethyl)phenoxyl radicals. J. Chem. Soc., Perkin Trans. 2, 1998(3), 697-700.

Jaeger, M. and H.B. Stegmann, Molecular recognition analyzed by EPR, ENDOR, and NMR spectroscopy. Angew. Chem. 1996. 108: p. 1943-1946; Angew. Chem., Int. Ed. Engl., 1996. 35(16), 1815-1818.

Buchbeiträge

Voigt M. and  Jaeger, M. Chapter 36 - In silico and in vivo ecotoxicity—QSAR-based predictions and experimental assays for the aquatic environment. In: Hong, H. (ed.) QSAR in Safety Evaluation and Risk Assessment. pp. 495-509. Academic Press, 2023. https://doi.org/10.1016/B978-0-443-15339-6.00018-7

Jaeger M. and Aspers R.L.E.G. Nuclear Magnetic Resonance of Steroids. In: Williams, A.J., Martin, G.E.,  and Rovnyak, D. (eds.) Modern NMR Approaches to the Structure Elucidation of Natural Products: Volume 2: Data Acquisition and Applications to Compound Classes.  pp. 275-314. The Royal Society of Chemistry, www.rsc.org, 2017. DOI:10.1039/9781849734684

Mecke, R., H.H. Jäger, and M. Jäger. Aroxyl Radicals in “Landolt-Börnstein/New Series. Numerical Data and Functional Relationships in Science and Technology”, New Series, Vol. II/ 26. c, Springer-Verlag, Berlin, Heidelberg, New York 2004. 

Projekt-/Bachelor-/Masterprojekt- und Masterarbeiten 

2022

Schaffarzyk, R.; Entwicklung eiiner Methode zur Identifizierung ausgewählter Pflanzenschutzmittelwirkstoffe durch experimentellen Nachweis mittels Raman- und SERS-Spektroskopie und Dichtefunktionaltheorie-basierten Spektrenanalysen. M.Sc.

2021

Wilbert. D.; Entwicklung einer SERS-Methode zum Nachweis von Pestiziden auf Gemüseproben. B.Sc.

Menart, J.; Untersuchung von regionalen Klärwässern auf ausgewählte Substanzen der EU-Watchlist mittels HPLC-ESI-Q-TOF-MS. B.Sc.

Gronau, T.; Simulation und Analyse der Schwingungsspektren von Pflanzenschutzmitteln mittels Dichtefunktionaltheorie. B.Sc.

Tiebe, S.; Untersuchung von Fließgewässern hinsichtlich der Anwesenheit und Konzentration unterschiedlicher Pharmazeutika mittels Hochleistungsflüssigkeitschromatographie gekoppelt mit Elektrospray-Ionisation-Quadrupol-Time-Of-Flight-Massenspektrometrie, B.Sc.

Sack, M.; Über die Entwicklung eines einfachen und robusten analytischen Tests zum vor-Ort- Nachweis von „Badesalzen“, B.Sc.

Sandmann, P.; Ökotoxizität ausgewählter chemischer Substanzen, B.Sc.

2020

Schöttl, J.; Entwicklung einer SERS-Methode zum Nachweis von Imidacloprid auf Polylactidgewebe mithilfe von Goldnanopartikeln, B.Sc.

Mahler, L., Anwendung prozessanalytischer Methoden auf mikrobiologische und chemische Reaktionen, M.Sc.

Bartels, I., UVC-Degradation und Ozonung ausgewählter Schadstoffe in Abwässern und Analyse ihrer Abbauprodukte mittels HPLC-ESI-Q-TOF-MS, M.Sc.

2019

Lamers, D., Optimierung von SERS-Untersuchungen von Pestiziden in Lösung und auf verschiedenen Substraten, B.Sc.

Votel, L., Untersuchung des photoinduzierten Abbaus von Iod-Kontrastmitteln und Metoprolol mittels HPLC-MS, B.Sc.

2018

Servatius, C., Untersuchung des Carotinoidgehaltes von Pflanzenteilen mittels mobiler Raman-Spektroskopie während des Reifeprozesses, M.Sc.

Arndt, S., Degradation von Metoprolol und Sulfamethoxazol in Wasser unter Laborbedingungen durch Elektrolyse und Photolyse, B.Sc.

Hentschel, B., Comparison of photo-induced degradation and mineralization of five fluoroquinolones in ultrapure water and surface water using HPLC-ESI-qTOF-MS and TOC, B.Sc.

Theiß, N., Photo-induzierte Degradation von Antiobiotika mittels UV-A Licht, B.Sc.

2017

Koza, T., Anwendung von Green Chemistry und Process Analytical Technology im Mikroreaktionssystem zur Synthese einer Biomasse-basierten Plattformchemikalie, M.Sc.

Hermsen, A., Surface-Enhanced Raman Spectroscopy: Entwicklung eines Nanopartikel basierten Substrates und Anwendung auf Neonicotinoid-Pestizide, M.Sc.

Tetzlaff, T., Mikro-Prozess-Analytik 2.0: Optimierung eines katalytischen Prozesses der Grünen Chemie, B.Sc.

Klein, J., Der Reifegradindex für Tomaten: Reifegradbestimmung von Tomaten verschiedener Reifestadien mittels portabler Ramanspektroskopie und Betrachtung des Nachreifungsprozesses nach der Ernte, B.Sc.

Wirtz, A., Mikro-Prozess-Analytik einer Fermentation und Isoamylacetatherstellung, B.Sc.

Bartels, I., Photo-induzierte Degradation und Evaluierung potentieller Umwelttoxizität ausgewählter Antibiotika und deren Photoprodukte anhand von MHK, B.Sc.

Savelsberg, C.,Untersuchungen von Pharmazeutika in Oberflächengewässern und Abwässern mittels hochauflösender HPLC-MS und MSⁿ, B.Sc.

2016

Friesen, A., Mikro-Prozess-Analytik mit spektroskopischen Methoden, M.Sc.

Barbarino, F., Optimierung der Wasserdampfdestillation ausgewählter Phenole in Klärwerken und Auswertung mit GC-MS und Vergleich mit der DIN-Norm 38409 "Phenol-Index", M.Sc.

Hermsen, A., Untersuchung von Photodegradanten von Pharmazeutika bezüglich ihrer Hemmung gegen Pseudomonas putida und Pseudomonas fluorescens, B.Sc.

2015

Legner, R., Mikro-Prozess-Analytik: Eine Kombination von Mikroreaktionstechnologie mit low-field NMR, M.Sc.

Häfner, S., Mikro-Prozess-Analytik: Eine Kombination von Mikroreaktionstechnologie mit Schwingungsspektroskopie, M.Sc.

Strube, M., Analysis of environmental relevant compounds with electrospray ionization trapped ion mobility spectrometry - mass spectrometry (ESI-TIMS-MS), M.Sc.

Ridene, L., Methodenentwicklung zum Nachweis von Pharmazeutika und endokrin wirksamen Substanzen im Krefelder Abswasser mittels LC-MS - Vergleich von LC-Ionenfalle-MS und LC-QTOF-MS, B.Sc.

Mitglieder der Arbeitsgruppe Martin Jäger